ギャンブル好きの父親が借金を残したまま蒸発し、取り立て人に家を追い出され、桃園奈々生は途方に暮れていた。そんなとき、犬に追われている優男ミカゲを助けたことをきっかけに、互いに打ち解ける。ミカゲは「家を譲る」と言い残して立ち去り、奈々生は半信半疑のまま教えられた場所に行くと、そこは廃れた神社が存在し、神使の巴衛、鬼火童子の鬼切・虎徹が住んでいた。ミカゲは神社の土地神であり、奈々生は神社を家として与えられたと共に、ミカゲが20年以上放棄していた土地神の責務も譲渡されたのであった。こうして神使達との共同生活を始めて、当初は冷たい態度を示す巴衛と反発しあっていた菜々生であったが、彼の忠誠心や性格を知るうちに恋をするようになっていく。一方で、奈々生は巴衛に助けられながら任務をこなし、様々な神との出会や困難に立ち向かい、神様として成長していく。
High schooler Nanami Momozono has quite a few problems of late, beginning with her absentee father being in such extreme debt that they lose everything. Downtrodden and homeless, she runs into a man being harassed by a dog. After helping him, she explains her situation, and to her surprise, he offers her his home in gratitude. But when she discovers that said home is a rundown shrine, she tries to leave; however, she is caught by two shrine spirits and a fox familiar named Tomoe. They mistake her for the man Nanami rescued—the land god of the shrine, Mikage. Realizing that Mikage must have sent her there as a replacement god, Tomoe leaves abruptly, refusing to serve a human.
Rather than going back to being homeless, Nanami immerses herself in her divine duties. But if she must keep things running smoothly, she will need the help of a certain hot-headed fox. In her fumbling attempt to seek out Tomoe, she lands in trouble and ends up sealing a contract with him. Now the two must traverse the path of godhood together as god and familiar; but it will not be easy, for new threats arise in the form of a youkai who wants to devour the girl, a snake that wants to marry her, and Nanami's own unexpected feelings for her new familiar.
