講談社刊「週刊少年マガジン」連載の久米田康治の人気ギャグ漫画を原作にしたテレビアニメのシリーズ第二弾。本作は、通称“絶望先生”とあだ名される超ネガティブ教師の糸色望を中心に、超ポジティブ少女の風浦可符香、超几帳面少女の木津千里、不下校少女の小森霧など、個性的な生徒たちにより、独特な世界観の中でシニカルなストーリーが展開される。また、『ネギま!?』『魔法少女リリカルなのは』などの新房昭之が監督を担当している。
More crazy antics abound as Nozomu Itoshiki (a.k.a Zetsubou-sensei), who is the worlds most negative person, tries to teach class 2-F about how life is filled with despair and darkness. A harder task than it first may seem, with his students being far from ordinary themselves, including the likes of the most positive girl he has ever met, his very own stalker, a foreign exchange student with split personalities and a perfectionist acting class president, due to the fact the real class president can't be seen by anyone, among others.