社会現象を巻き起こした庵野秀明監督によるオリジナルTVシリーズをリビルド(再構築)し、新劇場版として生まれ変わった全4部作の第3弾となるSFアクション・アニメ。また併映作品として、2012年夏に開催された<特撮博物館>で話題を集めた庵野秀明企画、樋口真嗣監督、スタジオジブリ製作の特撮短編映画「巨神兵東京に現わる」も『劇場版』にて同時上映が実現。
Fourteen years after third impact, Shinji Ikari awakens to a world he does not remember. He hasn't aged. Much of Earth is laid in ruins, Nerv has been dismantled, and people who he once protected have turned against him. Befriending the enigmatic Kaworu Nagisa, Shinji continues the fight against the angels and realizes the fighting is far from over, even when it could be against his former allies. The characters' struggles continue amid the battles against the angels and each other, spiraling down to what could inevitably be the end of the world.